While coronavirus continues to impact the tournament, the standout tie of the weekend goes on as England face Wales at Twickenham.
The Welsh may have lost four of the last five meetings between the pair, but crucially won last year’s match up as they cruised to the Six Nations Grand Slam in 2019.
A victory could lift Wales above England in the table, which leaves this one finely poised for a titanic tussle.
England will seek to make home advantage count and put real pressure on leaders France. Eddie Jones’ men are a short 1/6 to pick up the winand at 5/1 to win by a 6-10 point margin.
Wales are trying to stave off a third loss on the spin and sit at 9/2 to claim a much-needed victory.
But at full throttle, there isn’t much to choose between the sides with a tie at 33/1. If you fancy a surprise,Wales to be winning at half time is 9/4.
The loss of Sam Underhill is a huge blow for England. His replacement Mark Wilson has only played one Gallagher Premiership match since the World Cup, but his dog-like work rate and big presence should compensate.
The line-out is where the pendulum could swing though, as George Kruis comes up against Welsh skipper Alun Wyn Jones.
Whoever gets hold of it there could then help release speedsters Jonny May and George North to do the damage.
The hosts’ May is6/1to open the scoring, with team-mate and fellow winger Anthony Watson at 13/8 anytime.
England captain Owen Farrell is 5/1 to score anytime.
As for Wales, Liam Williams is 12/1 to break the deadlock and we go 11/5 for North to make it try time, anytime.
Where: Twickenham, London
When: 4:45pm, Saturday 7th March 2020
How to watch: ITV 1 / S4C
All Odds and Markets are correct as of publishing.