Europe have won six of the last eight instalments of the Ryder Cup and are 6/4 to extend their run with a victory in 2012 at Medinah Country Club.
The good news for the US is that they have won two of the last three on home soil and they are 4/6 to triumph in Illinois.
Identifying the tournament winner is only one of a hatful of markets available for punters looking at Ryder Cup betting odds.
Which individual players will shine is another popular option, with the 24 players all hopeful of repeating the achievement of Larry Nelson in 1979, who was the last golfer to achieve the perfect performance of five points from a possible five.
Europe fans will be expecting big things from world number one Rory McIlroy and he is the 5/1 favourite to accrue the most individual points for Europe.
For the US, it is no surprise to see Tiger Woods as favourite to score the most points for them at 5/1 and he has accomplished this feat in his last two Ryder Cups.
It is also Woods that heads the market at 9/1 to register the most points from all 24 players.
Although the winning margin was only one point in 2010 at Celtic Manor, the majority of recent Ryder Cups have seen a runaway winner.
Indentifying the correct winning margin from a host of small brackets is another betting opportunity, while some punters may fancy a crack at tipping the actual winning score.
Alternatively, other markets include whether there will be a hole in one achieved or not over any of the three days of combat, which team will be ahead on each particular day and who will score the most points from the Ryder Cup debutants.
All odds and markets correct as of publication