The meeting of the two sides tonight in the UEFA Nations League will be a reunion of the winner-takes-all clash last October.
The pair met at the Cardiff City Stadium with a World Cup play-off place at stake.
James McLean scored the only goal of the game to knock Wales out.
Martin O’Neil’s men are unbeaten in their last seven competitive away games and are 15/4 to win this one.
Wales are 10/11 to rip up the form book and win. There’s been three draw’s in the last six meetings between the two nations.
The last two stalemates have been goalless. This one to end 0-0 is 5/1.
Five of Wales’ last eight goals in competitive home matches have been scored by Gareth Bale.
His presence will be vital in this one. The news of Hal Robson-Kanu’s international retirement will mean more responsibility on the likes of Ben Woodburn and Tom Lawrence.
Giggs may well play an attacking 4-2-3-1 formation with Bale taking Harry Wilson’s place in the side.
The visitors are little more stretched with McLean injured and are already without Shane Long, Robbie Brady and James McCarthy to name a few.
O’Neil should start Darren Randolph in goal but play a five-man midfield including Wolves’ Matt Doherty and Championship pair Alan Browne and Callum O’Dowda.
The Irish could be expected to go 4-5-1 with Jonathan Walters up front.
Gareth Bale to score and Wales to win is 15/8.
Aaron Ramsey should take up one of the positions in the attacking three and will be a big threat playing off Sam Vokes.
The Republic will be very compact but the likes of O’Dowda, Hendrick and Walters could be potent on the counter-attack.
Shane Duffy scored for Brighton against Manchester United last month and will have to be watched at set-pieces.
Venue: Cardiff City Stadium
How to watch: Sky Sports Main Event / S4C
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All Odds and Markets correct as of date of publication