Pep Guardiola is expected to rotate his line-up from that which won 3-1 at Santiago Bernabeu over the weekend.
Despite this, the first eleven will still feature a wide array of international talent, including the likes of Gerard Pique, Dani Alves, Andres Iniesta and David Villa.
They are 1/20 to overcome an Al Sadd side whose most recognisable players are Algerian full back Nadir Belhadj and former Lyon and Galatasaray winger Kader Keita.
It is 9/1 that the teams play out a draw in 90 minutes, with an Al Sadd victory priced at an understandably huge 25/1.
In order to find better value on backing a Barcelona victory, score-line betting could prove the best method.
Whilst Barca are 1/7 to be leading at half-time and full-time, you can get 6/1 on a 4-0 win for the Spanish side, 16/1 on a 4-1 Catalan triumph, or for braver punters, it is 16/1 for Guardiola’s men to sweep everything before them with a 7-0 win.
Punters could also find value in looking at whether the total amount of goals scored in the game will be an even or odd number.
It is 9/10 an odd number of goals are scored, with 17/20 the price attributed to an even amount of strikes in the contest.
With an emphatic Barcelona win to be expected, it could pay dividends to take advantage of those 9/10 odds on an odd number of goals, covering punters for a 3-0, 5-0, or 7-0 Barcelona win.
The 3-0 and 5-0 score-lines in the Spanish giant’s favour are priced at 5/1 and 7/1 respectively.
Pedro’s incision along with the immense creativity of Iniesta, and unflappable nature of Villa’s finishing, makes this match seem almost like a foregone conclusion and the best way to make bigger profits from this game would appear to be by backing big Barcelona wins in the score-line markets.