Carlisle and the MK Dons are two of the three co-leaders at the head of League One and will be keen to build on their impressive home records when they host Brighton and Rochdale respectively.
MK Dons have won all of their three fixtures at stadium:mk and they have been especially strong defensively as they have only conceded one goal.
However, they host a Rochdale side next which defeated them in three of their four meetings in League Two in the past four seasons, scoring ten goals in these four showdowns.
The Dons are 10/11 to beat Rochdale this time, but the visitors will fancy their chances of defying odds of 3/1 as they are still unbeaten on their travels.
Carlisle have also only let in one goal at home and will be able to include emergency loan signing from Manchester United, Oliver Norwood, in their squad to entertain Brighton.
Norwood is 16/1 to open the scoring on his debut, with Carlisle 13/10 to collect another three points.
Brighton won the corresponding away fixture 2-0 last season and a repeat is priced at 11/1.
Meanwhile, Nigel Adkins is still searching for a first win as Southampton boss and his team are 4/5 to give it to him in his first home game in charge against Colchester.
Southampton are yet to win at home this campaign, but may have their work cut out against a team that have won two of their three away games and who they have failed to beat in their last six clashes.
Colchester left St Mary’s with a goalless draw last season despite playing over half the game with ten men and it is 9/1 for another 0-0.
Southampton are 5/1 to win League One despite sitting in the relegation places at present. See the full League One winners market.