History suggests that Leonardo should secure victory in his first game as Inter Milan boss and a home triumph over Napoli could be absolutely vital if they still harbour any realistic hopes of winning Serie A this season.
Under the stewardship of Rafa Benitez, Inter slipped 13 points off the top of the Serie A standings and they are now 5/1 to win the title, despite having two games in hand.
Inter have won their last seven games with Napoli at the San Siro and have only ever lost seven times at home against the opposition in 64 matches.
Serie A betting odds have Inter as the 8/11 favourites to take three points, but second-placed Napoli will be confident that they ensure that Leonardo gets off to a losing start.
Napoli have won their last four games 1-0 and it is 7/1 that this is the correct scoreline in their favour again, while it is 4/1 that they simply secure victory.
AC Milan currently lead the standings and they are 1/1 to win in the first round of fixtures after the winter break away at Cagliari.
Things in Milan’s favour include that they are unbeaten in 15 games against Cagliari and they have not lost in their first game of a new year since 1997.
Cagliari are 11/4 to beat Milan and may be relying on top-scorer Alessandro Matri for a goal as he netted in both fixtures against the Rossoneri last season.
Elsewhere, Juventus are fancied to extend their unbeaten run in all competitions to 19 games as they entertain a Parma side struggling towards the foot of the Serie A table.
Juventus are 2/5 to collect a victory that will ensure they remain fully involved in the title picture, with Parma 7/1 to secure just a second away win in the league this season.
A £10 bet on Napoli beating Inter 2-0 could lead to a return of £180. New Ladbrokes customers can sign up here for a free £10 bet.