PSV have endured a dreadful time against Scottish opposition in the past, but they take the first step towards setting the record straight when Rangers head to Holland for the first leg of the Europa League second round tie.
It is 8/15 in the Europa League betting that PSV beat Rangers and win for the first time against Scottish opponents at the seventh attempt.
What may be more worrying for PSV fans is that they have lost all of their three home games against teams from Scotland, with two of these defeats coming against Rangers.
However, Fred Rutten’s team are unbeaten in their last nine Europa League games, which includes nine victories and two draws in their last 11 outings at the Philips Stadion.
Rangers have reached the second round of the Europa League despite failing to win any of their last six European games, while it is ten fixtures since they last secured a victory on the road.
Betting odds of 11/2 are available on Rangers beating PSV, while it is 11/4 that the showdown ends in a draw.
With Rangers often proving tricky to beat in Europe, PSV may need to be patient in their quest to find the breakthrough.
Therefore, it may pay to take advantage of the 7/2 that the game is level at half time, but PSV are ahead by the final whistle.
Some good value may also be found in the first goalscorer market, with Balazs Dzsudzsak and Jeremain Lens both likely to be employed in advanced positions by PSV.
Dzsudzsak is 4/1 to open the scoring, with Lens 6/1 to break the deadlock.
For Rangers, Steven Davis is known for his late runs from midfield and looks overpriced at 16/1 to be the game’s first goalscorer.
A £25 stake on the scorecast PSV beating Rangers 2-0 and Dzsudzsak scoring first would return £450. New customers can sign up here for a free £25 bet.