Liverpool, Manchester City and Tottenham Hotspur will all be looking to get their respective Champions League campaigns underway with victory on Wednesday evening.
But the Premier League trio face some seriously strong opposition in their individual quests for three points.
Tottenham in particular have a tough task at home to Borussia Dortmund.
Here we take a look at the best bets from Wednesday’s Champions League action…
Liverpool v Sevilla
The Reds will be looking to make amends after a 5-0 hammering at Man City on Saturday.
Liverpool are the favourites at 4/6 but will be wary of a poor record against Spanish sides.
They’ve only won 14 of their previous 35 against teams from La Liga.
And that includes a 3-1 defeat to Sevilla in the 2016 Europa League final.
Los Rojiblancos are unbeaten so far this term, and similar to Liverpool, aren’t shy in front of goal.
We think a Draw and Both Teams to Score is the way to go at 15/4.
Feyenoord v Manchester City
In what should be a straightforward encounter, Man City travel to face Dutch champions Feyenoord.
The Sky Blues have an embarrassment of attacking riches up front and are 2/5 to see off their hosts.
A commanding 5-0 win at the weekend will put City in good spirits ahead of this one.
We’re expecting Pep Guardiola’s side to continue their unbeaten start at De Kuip Stadium.
The best bet looks to be Manchester City to Win and Over 2.5 Goals at 19/20.
However, if you fancy something a little longer, why not back Sergio Aguero to score first at 11/4?
Tottenham Hotspur v Borussia Dortmund
Spurs return to Wembley still looking for their first home win of the season.
Given Tottenham’s home record it may be worth siding with the visitors in this one.
Dortmund are top of the Bundesliga and yet to concede a goal in the league this season.
It’s a hefty 5/1 that they continue their impressive start and Win to Nil.
Dortmund on the Double Chance could also be worth siding with as an insurance bet at 8/13.
Click here for all the latest Champions League odds
All Odds and Markets correct as of the date of publication