The Toffees are unbeaten in nine opposing the visiting Latics, winning five, which should be enough to put punters off the 6/1 away side.
However, the four draws they have achieved in those meetings could lead some to be tempted by the 10/3 odds on them earning a replay in this match.
It seems highly plausible that goals will stem from this tie meanwhile, considering both teams have found the net in each of the past five meetings of this pairing.
Furthermore, Everton have scored and conceded in each of their games en route to this quarter-final, making the 9/10 odds on each team registering look tempting.
Bigger value can be found in total result markets however, where punters should be encouraged to back the winners of the match in company with the amount of goals.
David Moyes’ charges appear tremendous value at 9/4 to triumph in a game where both notch, a bet that would have succeeded in three of Everton’s four FA Cup outings this term.
It may be worth backing a slow-burning Toffees success too, given that the Blues have entered half-time level in half of their cup fixtures so far this season.
By contrast, Wigan have led at the break in three of their four cup outings, albeit all against lower league opposition, so the 3/1 that the hosts win a game that is level after 45 minutes appeals.
And with both teams expected to name their strongest line-ups possible, an abundance of potential scorer candidates can give punters a selection headache.
Kevin Mirallas could retain his place in the Toffees starting 11 after scoring in his last outing, and is an interesting 6/1 shot to open the scoring.
For the visitors, Arouna Kone may be worth backing to bag at any time at 5/2, in light of the four strikes he has in his last three games.
All Odds and Markets are correct as of the date of publishing.