The side with the best away record in the Premier League travel to a side that, until their defeat to Everton last weekend, had previously gone 18 games without losing at home.
Blackpool have played one away game more than everyone else due to issues with their Bloomfield Road Stadium, but have won three of their five away ties, including a victory at Anfield.
Ian Holloway has no fresh injury concerns from the side that rallied against Manchester City last weekend, and his passionate Wayne Rooney inspired rant may inspire his side as the look to continue their solid start in the Premier League – they are 10/3 to win.
Birmingham, despite their incredible home record, are in a shocking run of form with their only wins this season coming against Blackburn, MK Dons and Rochdale.
Birmingham are 5/6 to win and the Blues fans will be expecting a win against the newly-promoted team, but a draw offers the better value at 5/2 considering Birmingham have drawn four of their eight Premier League games this season.
With just five goals in four games at St Andrews this season, backing under 2.5 goals at 1/1 would seem reasonable, but Blackpool have scored in six consecutive matches against Birmingham and the Blues may have to come from behind to win.
Over 2.5 goals is available at 8/11 and for Birmingham to come from behind and win, you can get 8/1.
Alex McLeish is feeling the pressure slightly as Birmingham make their second worst start to a Premier League season, and he will ask for every effort from his side as he chases the three points.
However Birmingham have failed to score in their last three games, and in the same number of games Blackpool have scored six and a 2-0 win for Blackpool is available at 18/1.
Birmingham to win 2-1 is available at 7/1. See the full Birmingham vs Blackpool match betting odds market here.