Tottenham may tend to suffer the away day blues when heading on the road in September, but a trip to one of their favourite stomping grounds may improve their dismal record.
Spurs have failed to win the last 14 away games that they have played in September, which is a run that stretches back to a victory over Sunderland in 2001.
However, they are unbeaten in their last four trips to Upton Park, including victories in their last two visits.
They are 11/10 to beat West Ham again this year and extend their winning run against their London neighbours to six straight games.
West Ham are 5/2 to pick up their first victory over Spurs since 2006 and get one over on former boss Harry Redknapp.
The good news for West Ham is that injury will rule Jermain Defoe out of a return to Upton Park this season after he scored in both of Spurs’ victories over the Hammers during the last campaign.
Peter Crouch is still waiting for his first Premier League goal of the campaign and is 9/2 to open the scoring at West Ham to add to the four strikes he has already netted in European competition.
Gareth Bale could be a danger out wide and is 8/1 to score first in the Premier League betting odds and make it three league goals this season.
West Ham have only managed one goal in their last five Premier League matches against Tottenham but do look more of a threat with on-loan Victor Obinna in their line-up.
The Nigerian has made a positive impact since arriving from Inter Milan and opened his account for West Ham in their Carling Cup victory over Sunderland.
He is 8/1 to score first and potentially help West Ham climb off the foot of the Premier League table.
West Ham have only won two of their last 17 Premier League matches. See the complete West Ham vs Tottenham match betting market.