Brighton are the only team to have remained unbeaten at home in League One this season, but this record could be put under threat by Colchester, who are good value at 4/1 to take the three points.
Gus Poyet’s team are slowly coming back to the chasing pack at the head of League One, with the gap to second spot now just three points after a defeat at Bournemouth in their most recent outing.
They are the 4/6 favourites in the League One betting to get back to winning ways against Colchester, but the visitors have lost the fewest number of away games in the division.
Furthermore, Colchester have won on their last two visits to Brighton and on each occasion they have triumphed 2-1.
It is 14/1 in the correct scoreline betting market that Colchester seal a 2-1 victory again.
Despite their position towards the foot of the League One standings, Leyton Orient have been pretty solid at home and they can continue this with a victory over MK Dons.
Orient beat Sheffield Wednesday 4-0 in their latest home game and are 5/4 to ensure maximum points again, against the team to have lost the most away games in the division this season.
The Dons are in the play-off places despite their disastrous away form and are 2/1 to beat Leyton Orient.
Elsewhere, Sheffield Wednesday are fancied to recover from their defeat at Orient with a comfortable home win over Yeovil.
Sheffield Wednesday are much better at home than on their travels and are 8/13 to beat a Yeovil side currently in the relegation places in League One.
The Owls have also won their last three league games at home and have already beaten Yeovil on their travels this season.
A £25 stake on Sheffield Wednesday beating Yeovil 3-0 would return £275. New customers can sign up here for a free £25 bet.