The Iberian derby will always be more than just a friendly, but this particular match offers Portugal the chance to get one over the World and European Champions.
As both nations focus on a joint bid to host the 2018 World Cup, the friendly in Lisbon offers a chance for both nations to showcase their talents before a decision is made in two weeks time.
Unsurprisingly Spain are favourites, but what may be surprising is that the world champions are only 11/8 to beat Portugal.
That may be because under Paolo Bento, Portugal have registered consecutive victories over Denmark and Iceland in his two games in charge since replacing Carlos Quieroz.
But Bento will be without two in-form players in Benfica’s Fabio Coentrao and Porto winger Silvestre Varela as his side search for revenge for the 2010 World Cup defeat – Portugal are 2/1 to beat Spain.
Xavi will play a part in the match for Spain if he declares himself fit and Fernando Llorente will replace Fernando Torres.
Portugal have scored three goals in both games that Bento has taken charge of, and Cristiano Ronaldo has two of those six goals and the Real Madrid star is 6/1 to score first.
In the ten ties that these two have competed against each other, 27 goals have been scored with 20 going to Spain.
David Villa has 37 goals in 57 caps and is 5/1 to score first, although Fernando Llorente offers some value at 8/1 to score first after replacing the injured Torres.
Considering the goals between the two in their ties and the exhibition match that both Football Association’s will want to see, over 2.5 goals looks the best bet at 24/25.
Five of the 10 ties between the two have ended in a draw and that is priced at 9/4. See the full Portugal vs Spain betting odds here.