Bolton have triumphed on the other two occasions that they have previously been drawn against Fulham in the FA Cup and are 5/2 to claim victory at Craven Cottage this season that will book their place in the sixth round of the competition.
Owen Coyle’s team only reached the fifth round of the tournament in midweek when winning a replay at Wigan and are seeking a third successive victory in all competitions.
However, Fulham are unbeaten in six meetings with Bolton and are bidding to reach the quarter finals of the FA Cup for the third season in a row.
Fulham are also set to be boosted by the news that the influential Clint Dempsey should feature after recovering from a minor injury concern.
It is 11/10 in the FA Cup betting that Fulham beat Bolton and they have not been beaten at home since Boxing Day.
Meanwhile, Bolton have been knocked out of the FA Cup by a Premier League club in five of the last six seasons.
The last three showdowns between Fulham and Bolton have ended all square and it is 23/10 that the game ends in a draw that will force Bolton to play another replay.
Over/Under 2.5 goals
One thing that is for certain is that the tie is likely to be close, with only one of the last 12 meetings between the pair being won by more than a one-goal margin.
Furthermore, only two goals have been scored in the last three of these encounters, with the last pair both ending 0-0.
It is 8/1 in the FA Cup odds that the duo grind out another 0-0 draw, while 6/5 seems a reasonable price that only one of the two teams find the target.
However, perhaps the best alternative bet outside of the match odds may prove the 4/6 that fewer than 2.5 goals are scored at Craven Cottage.
A £25 stake on Fulham beating Bolton 1-0 would return £175. New customers can sign up here for a free £25 bet.