Wycombe saw off lowest-ranked side Stourbridge in the Third Round to reach this stage of the competition for only the second time in their history.
The last time the Chairboys reached the Fourth Round they went on an epic run to the semi-finals in the 2000-2001 season.
Elsewhere, there are also two tasty derbies to look forward to with Chelsea taking on Brentford at Stamford Bridge while Derby County will host East Midlands rivals, Leicester City.
Meanwhile, holders Manchester United will meet Wigan Athletic at Old Trafford and Sutton United or AFC Wimbledon will meet the winners of Cambridge United v Leeds United.
Former cup winners Michael Owen and Martin Keown were on hand to do the honours at BT Tower.
Here’s the Emirates FA Cup Fourth Round draw in full:
Tottenham Hotspur v Wycombe Wanderers
Derby County v Leicester City
Oxford United v Newcastle United or Birmingham City
AFC Wimbledon or Sutton United v Cambridge United or Leeds United
Plymouth Argyle or Liverpool v Wolverhampton Wanderers
Southampton or Norwich City v Arsenal
Lincoln City or Ipswich Town v Brighton and Hove Albion
Chelsea v Brentford
Manchester United v Wigan Athletic
Millwall v Watford
Rochdale v Huddersfield Town
Burnley or Sunderland v Fleetwood Town or Bristol City
Blackburn Rovers v Barnsley or Blackpool
Fulham v Hull City
Middlesbrough v Accrington Stanley
Crystal Palace or Bolton Wanderers v Manchester City
Ties will be played the weekend of Friday January 27 – Monday January 30.
Best of luck to all of those involved!
Keep your eyes peeled to Ladbrokes News and @Ladbrokes for plenty more Emirates FA Cup build-up and exclusive content.
As the official bookmaker of the FA, we’ve already been at the heart of the conversation having been on the hunt for the next Non-League hotshot in our #VardyVerdict series.
We’ve also given out thousands of free bets thanks to our incredible Back the Underdog! offer.
All Odds and Markets are correct as of the date of publishing