The Foxes will travel to take on Fleetwood Town, while Norwich City play host to Antonio Conte’s Blues.
We’ve picked out the best bets for both matches…
Fleetwood Town v Leicester City (12:45, BBC)
Leicester have departed the competition at the third round stage in six of the last 11 seasons.
Fleetwood, on the other hand, have never progressed past this point in their 110-year history.
However, we think the value lies in the goals market.
Claude Puel’s men have bagged 22 times on the road so far this season in all competitions.
They could take advantage against a Cod Army outfit that have conceded two or more in each of their last three games at Highbury.
And with Jamie Vardy returning to his old stomping ground, is it written in the stars that the England ace will cause trouble for his former employers?
Norwich City v Chelsea (17:30, BT Sport)
The last 12 fixtures between these two clubs have produced 10 Chelsea victories.
The West Londoners have kept clean sheets in eight of those meetings.
Against a Canaries side that are amongst the lowest scorers in the Championship, Antonio Conte’s men should have no trouble in recording a shutout.
In terms of goalscorers, Michy Batshuayi is likely to start the match and will be looking to add his five goals already this season in domestic cup competitions.
Nelson Oliveira is best-priced for the hosts at 5/2 Anytime.
All Odds and Markets are correct as of date of publication