Newcastle will count themselves unlucky to be heading into this game level on aggregate, after having two goals controversially chalked off in the first leg.
And whilst the 0-0 scoreline wasn’t the worst the Magpies could have achieved, they now face an uphill task in justifying 16/5 odds to win in 90 minutes here.
Instead, their chances of obtaining a draw look more likely against such a stern home side, one which hasn’t lost in their last six outings on their own patch in all competitions.
The stalemate is 12/5, whilst another 0-0 draw, which in turn would necessitate extra-time in the tie, is available at 7/1.
Any form of score draw would see Newcastle advance, and punters fancying the Toon to do enough can have 7/2 on each team finding the net in a match that ends level.
It is the home side that look the smartest bet however, with the 9/10 shots gunning for a sixth win in their last seven matches in Ukraine.
Metalist have won all three of their European home fixtures this season too, and conceded only once across that trio of games.
A Metalist clean sheet is 17/10, and the Ukrainian hosts can also be backed as tempting 11/5 chances to beat Newcastle without conceding.
It is interesting to note that Metal have most regularly started slowly in Europa League competition this term, meanwhile.
During each of their four wins at the group stage, Kharkiv headed into the break level with their opponents.
They therefore look a terrific bet to be drawing at half-time before going on to win here, at big 10/3 odds.
And betting on a Metalist success featuring goals aplenty could too prove profitable, considering the hosts scored at least twice in four of their six Group K games.
At least three strikes occurred in three of their last five home games in all competitions too, and they make great appeal at 21/10 to win a game involving over 2.5 goals.
All Odds and Markets are correct as of the date of publishing.