However, with Stoke City, Birmingham City and Fulham all in action tonight, there are plenty of ways to make a very tidy profit.
Thun vs Stoke City (6.30pm)
Stoke travel to Switzerland for their first-leg game against Thun this Thursday having already seen off the even more obscure Hajduk Split in the last qualifying round.
The Potters head into this game as 7/5 favourites and look good to head back to the Britannia with a lead.
They were solid in their goalless draw with Chelsea at the weekend and, with Thun winning just one of their previous five games, backing a victory for Stoke looks like the bet.
Nacional vs Birmingham (7.45pm)
Championship side Birmingham have had a mixed start in the second tier with a win and a defeat in their opening two games.
Meanwhile, Portuguese side Nacional have drawn their opening game in their top-tier league and comfortably dispatched FH and Hacken in earlier Europa League rounds at home.
The Blues haven’t won a competitive away game since a 1-0 victory over West Ham United in February so back Nacional to win at 5/6.
Fulham vs Dnipro
Fulham’s Europa League credentials are already established thanks to their final appearance in 2010.
They should continue their good European form on Thursday with a win against Dnipro of the Ukraine.
The Cottagers haven’t so much as conceded a goal in their four competitive home games this term and should comfortably see off Dnipro in the first leg.
Back Martin Jol’s men to win at 4/6.