Beaten finalists last term, the Reds welcome Leeds to Anfield to vye for a semi-final spot, and despite the Whites’ fall from grace in the 21st century, Garry Monks’ men are showing signs of revival.
The Yorkshire outfit have risen up the Championship table, and head to Merseyside with nine wins from their last 13 games in all competitions.
It’s a remarkable turnaround after the club opened with one win in six and reports suggested Monk’s time at Elland Road was nearing a very early end.
The two sides haven’t met since 2009, and unsurprisingly, no members from either side will be around here.
Klopp has regularly stated he will take cup competitions seriously, though he will be without Philippe Coutinho who is set to miss several weeks through injury.
Daniel Sturridge and Roberto Firmino also look set to miss out, as will Adam Lallana.
Thankfully the former Dortmund boss can still call upon plenty of attacking talent, and Divick Origi may well get another chance following his goal against Sunderland.
Monk will be hoping Chris Wood can cause the Liverpool defence a few issues, and the big striker is 9/1 to score the first goal at Anfield, having already netted 12 times this season.
The Premier League outfit will also need to be on guard for the talents of Kemar Roofe.
But Leeds are in-form and finally appear to have found stability under Monk, they have nothing to lose, and are more than capable of giving their Premier League hosts a problem or two.
All Odds and Markets are correct as of the date of publishing