Ladbrokes give Leeds betting odds of 4/6 to beat their Yorkshire rivals, which would at worst retain their spot in the Championship play-off places.
Leeds are currently in the middle of a five-game unbeaten run, while only Crystal Palace have lost more away games in the Championship this season than Barnsley.
Barnsley are 9/2 to repeat their success at Oakwell back in September, with the draw available at 5/2.
Perhaps the biggest midweek Championship game is at Cardiff, where Leicester are the visitors to Wales.
Leicester have surged onto the cusp of the play-off places with five straight league wins and are 9/5 in the Championship betting to continue this sequence at Cardiff.
The Foxes have won both of their last two encounters with Cardiff, including when triumphing in the away leg of their play-off clash last season.
Cardiff are unbeaten in their last four home games and will want to bounce back to winning ways following their defeat at fellow promotion contenders Nottingham Forest.
It is 6/4 in the Championship odds that Cardiff beat Leicester, while the draw can be backed at 23/10.
QPR still top the table by five points and they will be keen to consolidate their advantage with a home win over Ipswich.
Ipswich have turned a corner of late by going five matches unbeaten and they have won four of their last five games with QPR.
But no team has scored more home goals than QPR in the Championship this season and they are 8/11 to land the spoils.
Ipswich’s betting odds are 4/1 to beat QPR and it is 5/2 that the game ends all square.
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