Harry Redknapp will take his side to the San Siro for their biggest European tie since playing Real Madrid in 1985, and Redknapp can boast a winning record over his opposite number.
Before Redknapp joined Spurs, Benitez was unbeaten against the North London club in nine attempts, but subsequently lost three of the five encounters between the two before he left for Italy.
Rafa Benitez, for all his faults, is the master tactician when it comes to Europe, leading Valenica to Uefa Cup success and Liverpool to two Champions League finals with one victory, and Inter are 4/6 to beat Spurs.
Harry Redknapp will be without the suspended Rafael van der Vaart and injured Ledley King as fears over his long-term future grow after King was ruled out for a month.
Spurs have won one, lost one and drawn one against Italian opposition in Europe and are 4/1 to emerge from the San Siro with a win.
Both sides have scored six goals in their two Champions League ties and there is nothing to suggest that this game will be low scoring with both sides capable of scoring plenty of goals.
The five ties that the two managers contested as Liverpool and Spurs managers produced 18 goals and total goals over 3.5 is available at 7/4.
After his hat-trick against Werder Bremen, Samuel Eto’o is the top scorer in the Champions League with four and is 1/1 to score any time.
FC Twente vs Werder Bremen
Bremen have won only one of their last 15 Champions League away ties and are 2/1 to win.
Spurs are 12/5 to top Group A. See the full UEFA Champions League football betting odds market here.