Sevilla will need to continue their insuperable home record against Portuguese opposition when looking to overturn a first-leg deficit against Braga to reach the group stages of the Champions League for the third time in four years.
Matheus grabbed the only goal of the game a week ago as Braga claimed a 1-0 victory that put them on course to participate in the group stages of the competition for the first time in their history.
However, if they are to complete the job they will need to fare better on Spanish soil than the likes of Benfica, Nacional and Vitoria have done in the past.
Sevilla have never lost at home to Portuguese opponents, but even avoiding defeat may not be enough to secure a passage into the group stages.
They are 2/5 to win on the night, but are a longer 4/6 to qualify as Braga could lose by one goal and still go through if they manage to score an away goal.
The two teams have met at the Ramon Sanchez-Pizjuan once before, in the 2007 UEFA Cup, when goals from Luis Fabiano and Ernesto Chevanton gave Sevilla a 2-0 win.
Fabiano is the 7/2 favourite to open the scoring again, ahead of teammates Freddie Kanoute and Alvaro Negredo.
Meanwhile, Braga were defeated 2-1 in the away leg of their clash with Celtic in the previous qualifying round, but went through thanks to a 3-0 victory in Portugal.
A repeat of the 2-0 success that Sevilla gained four seasons ago is 5/1, while an attacking display could lead to more goals, with 8/1 available for a 3-0 home win.
Sevilla’s best Champions League performance was reaching the last 16 in 2008 before being eliminated by Fenerbahce. They are 33/1 to win the Champions League.