In the last two seasons, a quarter-finalist has progressed despite being two goals down from the first leg.
Last term, FC Porto shocked Bayern Munich with a Ricardo Quaresma inspired 3-1 win in Portugal.
When the two met six days later at the Allianz Arena, the Bundesliga champions showed their class with a 6-1 victory that saw them advance, with Robert Lewandowski scoring twice.
The campaign before that, Paris Saint-Germain seemingly had one foot in the semi-finals after a 3-1 triumph over Chelsea.
However, the surprise duo of Andre Schurrle and Demba Ba popped up with important strikes at Stamford Bridge that saw the Blues progress.
Both of these took place with the team that eventually progressed losing away first before turning it round at home.
This is a new trend in Champions League football, with none of the nine quarter-finals before the west Londoner’s turnaround seeing a side make it through despite trailing by two goals in the first leg.
You have to go back to the 2003/04 campaign for the next time this phenomenon occurred and coincidentally it was Real Madrid who felt the wrath of this particular reverse on that occasion.
The La Liga outfit made easy work of Monaco in a 4-2 win at the Bernabeu, but Fernando Morientes, who was on loan from Madrid, scored the vital away goal in a 3-1 win as the French side eventually made it all the way through to the final.
Los Blancos chances of making it through are also boosted by the fact that they lost 2-0 to a German team at this stage of the competition in the 2013/14 season, albeit in the second leg, and still made it through.
A 3-0 romp in Madrid saw Borussia Dortmund look essentially out of the tournament, but two goals from Marco Reus in Germany made things much tenser than expected.
Backing Real to earn the same result they managed against Dortmund is priced at 15/2.
All Odds and Markets are correct as of the date of publishing.