Harry Redknapp enters the second round of the Champions League group stage with just one recognised centre-back.
Injury has hit William Gallas, Ledley King, Michael Dawson and Younes Kaboul leaving just Sebastien Bassong, who will be partnered at the centre of defence by Vedram Corluka.
The two played alongside each other in Spurs’ 1-0 loss to West Ham on Saturday and Redknapp knows his side can’t afford to lose a home tie if they want to progress to the qualifying stages – Twente are 7/2 to win.
History suggests this won’t be a problem with Spurs losing just three times in 63 European times at home and they are 4/5 to win at White Hart Lane.
Peter Crouch will be hopeful of working the Twente defence who have just kept one clean sheet in their last 18 European matches, excluding qualifiers, and Crouch has found the net nine times in eleven starts.
Crouch is 4/5 to score anytime and Spurs are 9/4 to win to nil.
Inter Milan vs Werder Bremen
Werder beat Inter 2-1 the last time these two sides met in 2008, but Inter are on a seven match unbeaten streak in the San Siro and Rafa Benitez will want to bounce back quickly after falling to a 1-0 defeat to Roma in Serie A last weekend.
With Werder winning just one of their previous 14 away Champions League ties, Inter are strong favourites to win at 8/13.
Despite proving his Champions League credentials at Liverpool, Rafa Benitez is on a poor streak, winning just one of the last six matches he has taken charge of in the competition.
With all teams taking a point from their first game Group A will prove to be tight, but Inter are 4/6 to top the group.