Suspension has ruled Didier Drogba out of a game against former club Marseille, meaning that the pressure will be on Nicolas Anelka to fire Chelsea to victory at Stamford Bridge.
Meanwhile, Chelsea have won 15 of the last 22 home games they have played in the competition, with their only defeat at Stamford Bridge in this sequence being their 1-0 reverse to eventual winners Inter Milan last season.
For Marseille, manager Didier Deschamps will hope to mastermind a victory against one of his former clubs.
Marseille failed to get their Group F campaign off to the greatest start with a defeat against Spartak Moscow and they are 10/1 to beat Chelsea to get their qualification aspirations back on track.
Anelka is likely to lead the line for Carlo Ancelotti’s team in Drogba’s absence and can draw confidence from the last time he faced French opposition in a Chelsea shirt.
Anelka was on target when Bordeaux visited Stamford Bridge in 2009 and also scored in the away fixture in the group campaign.
He is 7/2 to be the first goalscorer against Marseille , while fellow Frenchman Florent Malouda is 9/2 to open the scoring.
The other Group F game sees Moscow host MSK Zilina and immediately put right the fact that they failed to win a home game when they were last in the Champions League in 2007.
Moscow are 2/5 to beat Zilina, with the Slovakians 7/1 to cause a shock and take their first three points in the tournament this year.
Chelsea are 1/7 to top Group F after beating Zilina 4-1 in their opening game. See the entire Group F winners betting odds market.