A reaction is certainly needed at AC Milan, as they are yet to win on the road all season and have gone four without a win anywhere, which has contributed to them languishing in the bottom half of the Serie A standings.
However, one thing that Milan have tended to do well in recent seasons is upset and frustrate Barcelona, losing only two of the last five encounters between the pair.
Atletico Madrid are the only visiting team to leave the Nou Camp with a positive result this season and given Milan’s troubles, a Barcelona triumph as to be the pick at 2/9.
Given that Barcelona have conceded in three of their last four at home and Milan have netted in all of their away games this season, including 10 in their last five, a Barca victory in a game where both teams are on target is something to consider at better Champions League odds of 19/10.
Meanwhile, the 1/1 that Barcelona score 2-3 in the clash is reasonable.
Picking a winner in this one is not overly straightforward and so the best betting options may linger around the goal markets.
Ajax have suddenly found goals hard to come by, failing to trouble the scorers in their two Eredivisie games at home since losing 2-1 at Celtic in October.
However, Celtic have not scored an away goal in the Champions League this season, which includes blanks in the qualifying rounds against Elfsborg and Shakhter Karagandy.
Backing the 0-0 then suddenly looks a mammoth price at 11/1, with 20/21 on offer that both teams fail to find the scoresheet at the Amsterdam ArenA.
All Odds and Markets are correct as of the date of publishing.
Fancy a flutter? Sign up today to claim three £10 free bets when you bet £10.